The immunoregulatory effect of thalidomide on peripheral blood mononuclear cells in patients with thyroid-associated ophthalmopathy
10.3760/cma.j.issn.1000-6699.2013.07.011
- VernacularTitle:沙利度胺对甲状腺相关眼病患者外周血单个核细胞的免疫调节作用
- Author:
Hui HAN
;
Jiao HUANG
;
Xianfeng ZHANG
;
Qiaofeng TU
;
Chu ZHANG
- Publication Type:Journal Article
- Keywords:
Thalidomide;
Thyroid-associated ophthalmopathy;
Peripheral blood mononuclear cell;
Immunoregulatory
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(7):584-585
- CountryChina
- Language:Chinese
-
Abstract:
The immunoregulatory effect of thalidomide on peripheral blood mononuclear cells in patients with thyroid-associated ophthalmopathy (TAO) was investigated.The resuhs showed that thalidomide (50 μg/ml)inhibited the proliferation of PBMC significantly.Thalidomide inhibitied tumor necrosis factor-α,IFN-γ,and interleukin-6 secretion,as well as mRNA expressions.
