Preoperative Erythropoietin Administration in Patients With Prostate Cancer Undergoing Radical Prostatectomy Without Transfusion.
10.4111/kju.2014.55.2.102
- Author:
Byung Woo LEE
1
;
Min Gu PARK
;
Dae Yeon CHO
;
Seok San PARK
;
Jeong Kyun YEO
Author Information
1. Department of Urology, Inje University Seoul Paik Hospital, Seoul, Korea. yeoluvk@hanmail.net
- Publication Type:Original Article
- Keywords:
Blood transfusion;
Bloodless medical and surgical procedures;
Erythropoietin;
Jehovah's witnesses;
Prostatectomy
- MeSH:
Blood Transfusion;
Bloodless Medical and Surgical Procedures;
Erythropoietin*;
Humans;
Jehovah's Witnesses;
Prostate*;
Prostatectomy*;
Prostatic Neoplasms*;
Retrospective Studies
- From:Korean Journal of Urology
2014;55(2):102-105
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: In this study, we administered erythropoietin preoperatively to patients who underwent open radical prostatectomy without transfusion to increase their hemoglobin levels and investigated the efficacy of this procedure. MATERIALS AND METHODS: We evaluated 62 patients who underwent open radical prostatectomy performed by the same surgeon between June 2005 and January 2011. The 22 patients who refused transfusion were assigned to group 1; the patients who accepted transfusion were assigned to group 2. Before surgery, we administered erythropoietin beta to group 1 patients whose hemoglobin levels were <12 g/dL and retrospectively compared the clinical data of the two groups. We used the t-test and the chi-square test for statistical analysis. RESULTS: Mean preoperative hemoglobin levels in group 1 after erythropoietin administration (14.5 g/dL) were significantly higher than those in group 2 (13.59 g/dL, p=0.003). Moreover, the difference in the mean hemoglobin levels before and after surgery for group 1 patients (3.55 g/dL) significantly exceeded that for group 2 patients (2.08 g/dL, p=0.000). Additional analysis revealed no statistically significant differences in perioperative complications between the groups. CONCLUSIONS: Preoperative erythropoietin administration increased the safety margin of hemoglobin levels, and this strategy worked sufficiently well in our experience.
