Early predictive values of P-selectin, thrombus precursor protein and D-dimer for portal vein thrombosis after splenectomy in patients with portal hypertension
10.3760/cma.j.issn.1007-8118.2013.07.011
- VernacularTitle:监测P-选择素、血栓前体蛋白、D-二聚体对门脉高压脾切除术后门静脉血栓形成的早期预测价值
- Author:
Yunhai WEI
;
Huaping SHEN
;
Guolei ZHANG
;
Xuedong CHEN
;
Dayu WANG
;
Mingjie ZHANG
;
Wenxian CHEN
- Publication Type:Journal Article
- Keywords:
[Key word] Portal hypertension;
Portal vein thrombosis;
P-selectin;
Thrombus precursor protein;
D-dimer
- From:
Chinese Journal of Hepatobiliary Surgery
2013;19(7):526-529
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive values of P-selectin (P-sel),thrombus precursor protein (TpP) and D-dimer (D-D) in the early diagnosis of portal vein thrombosis (PVT) in patients submitted to splenectomy (or to devascularization).Methods The clinical data of 48 patients with portal hypertension (the PVT group,n=26; and the non-PVT group,n=22) who received operation in our hospital from 2009 to 2011 were retrospectively analyzed.Detecting the P-sel,TpP and D-D levels in the two groups of patients were done on preoperative day 1 and postoperative day 1,3,5,7,14.The SPSS software was used for statistic analysis.Results There were no significant differences on the preoperative day 1 levels of P-sel,TpP and D-D in the two groups (P＞0.05).The postoperative day1 levels of the three indicators in the PVT group were significantly higher than the non-PVT group (P＜0.05).Receiver operating characteristic (ROC) curves showed the area under curve (AUC) of P-sel was largest (0.893),followed by D-D,and TpP.The combined detection of the 3 indicators was highest,with the AUC up to 0.977.Conclusions Combined detection of P-sel,D-D and TpP levels were useful in the early diagnosis of PVT after splenectomy in patients with portal hypertension.
