Acute toxicity of trifluoropropyloxydihydroartemisinin (BB101) in monkey
- Author:
Doan Hanh Nhan
- Publication Type:Journal Article
- Keywords:
acute toxic
- MeSH:
toxicity;
Haplorhini;
animals;
Animal Experimentation
- From:Journal of Malaria and parasite diseases Control
2004;0(3):47-52
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Acute toxicity of injectable doses of 40mg/kg, 80mg/kg, 120mg/kg, 160mg/kg of BB101 (trifluoromethyl hydroartemisinine) corresponding to 1/10,1/5, 1/4, 1/3 of LD50 by injection on monkey was studied. With the doses of 40mg/kg and 80mg/kg, on monkey, normal living activity was still manifested except anorexia, weight loss, hair fall...Bad conditions had been aggravating with the increasing doses. At the dose of 120mg/kg, monkey died 2 days after interruption of toxic substance and at the dose of 160mg/kg, monkey died on the day N5.As regards biochemistry indices, BB101 in 5 consecutive days with the daily dose of 40mg/kg and 80mg/kg enhanced SGOT, SGPT, proteine and creatinine (in permitted intervals);with 120mg/kg and 160mg/kg enhanced SGOT and SGPT by 3-5 folds higher, other indices were in permissible intervals. As regards hematological indices; white blood count, red blood count and haemoglobine reduced
