The relationship between the serum prolactin, immunity and prognosis of the critical patients
10.3760/cma.j.issn.1671-0282.2013.02.016
- VernacularTitle:危重症患者血催乳素、免疫功能与预后的关系
- Author:
Songjing SHI
;
Tingting YOU
- Publication Type:Journal Article
- Keywords:
Prolactin;
Cell immunity;
Humoral immunity;
Critically ill;
Prognosis;
Endocrine system;
Immunoregulation;
Acute physiology and chronic health evaluation Ⅱ
- From:
Chinese Journal of Emergency Medicine
2013;22(2):180-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the relationship between the serum prolactin (PRL),immunity and prognosis of the critical patients.Methods The data of 80 patients with complete clinical data in the Intensive Care Unit of the Fujian Provincial Hospital during October 1,2010 to October 1,2011 were collected.The patients were divided into 2 groups according to the prognosis:death group and survival group.Fasting blood is extracted respectively on the morning of the 2nd day after they were admitted,the 4th day and the 8th day.Chemiluminescence immunoassay system was used to detect the serum PRL,flow cytometers to test peripheral blood T-lymphocyte subsets,and immunization rate nephelometry to check the 5 items for bumoral immunity in peripheral blood.The multi-factor repeated measure analysis of variance was used in the comparison of the two groups.Results Compared with those of the survival group,the serum PRL (P=0.037,0.036,0.030),the percentages of CD3+ (P=0.034,0.023,0.023),CD4+ (P =0.046,0.003,0.046) and CD8+ (P =0.040,0.039,0.045) cells of the death group were significantly lower.However,positive correlation exists between the value of serum PRL and the percentages ofCD3+,CD4+ and CD8+ cells (P=0.004,0.043,0.003):the higher the former,the higher the latter.Conclusions The change of cellular immunity is important for the prognosis of the patients.Downgradationof the cellular innunity indicates an undesirable prognosis.The serum PRL may work positively on cellular immunity.
