Mechanisms and risk assessment of cancer treatment-induced female fertility impairment

VernacularTitle:肿瘤治疗对女性生育力的影响及其机制与风险评估
Author: Caiyun LIAO ; Xiaoyan LIANG
Publication Type:Journal Article
Keywords: Neoplasms; Fertility; Surgical procedures,operative; Drug therapy; Radiotherapy
From: Journal of International Oncology 2013;40(8):614-617
CountryChina
Language:Chinese
Abstract: Surgical resection,radiotherapy and chemotherapy are the current mainstays of cancer treatments.During ovarian cystectomy,part of the normal ovarian cortex could be resected together with ovarian mass,which suppresses ovarian reserve postoperatively.This reduction in ovarian reserve is especially produced after resection of ovarian endometriomas.On the other hand,radiotherapy and chemotherapy may cause cell apoptosis,diminish blood supply in the ovaries and weaken the brake on follicular recruitment.Brought together,these mechanisms give rise to accelerated deprivation of ovarian follicles,and hence undermine fecundity of the affected individuals.Moreover,radiotherapy could result in alterations in structure and functions of uterus and other pelvic organs,which translate into increased incidence of obstetric complications later on.Currently antral follicular count and serum anti-Müllerian hormone are the most sensitive and accurate measurements of ovarian reserve.