Polypeptide modified coating, a bone tissue engineering material, is used for treatment of osteoporosis
10.3969/j.issn.2095-4344.2013.42.018
- VernacularTitle:骨组织工程材料多肽修饰涂层在骨质疏松中的应用
- Author:
Cong WANG
;
Wen YUAN
;
Xiaodong WU
;
Haiyong AO
- Publication Type:Journal Article
- Keywords:
biocompatible materials;
tissue engineering;
osteoporosis;
osseointegration
- From:
Chinese Journal of Tissue Engineering Research
2013;(42):7455-7461
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The biological substances fixed onto the implant surface, including specific proteins, enzymes, polypeptides, could promote the proliferation and differentiation of osteogenic cells in order to achieve a good osteogenic effect.
OBJECTIVE:To introduce the biological characteristics of the arginine-glycine-aspartic acid (RGD) peptides, cellbiological behavior and implant osseointegration in osteoporosis.
METHODS:Authors retrieved the relevant articles in PubMed database (January 1984 to January 2013), Wanfang database (January 2002 to December 2012) and CHKD database (January 2002 to December 2012) using the key words“RGD peptides, osteoporosis, bone marrow mesenchymal stem cells, osseointegration, osteoblast, induced differentiation”. Papers were included concerning the biological characteristics of RGD peptides, the biological behavior of cells and the bone-implant integration in osteoporosis.
RESULTS AND CONCLUSION:Osseointegration on the surface between implant and bone tissue can be further improved by grafting biological y active substance. Bionics modification, to simulate the extracellular matrix environment in vivo, can promote celladhesion and growth, which is an effective way to improve osseointegration and is also an important direction of research in the field of tissue engineering recently. The future research is focused on designing specific and efficient polypeptides and simple and effective fixation methods.
