Response of plasmodium falciparum to artemisinin in vivo and in vitro in Phu Rieng ruber plantation (1998 and 2001)
- Author:
Ngo Viet Thanh
- Publication Type:Journal Article
- Keywords:
plasmodium falciparum
- MeSH:
malaria;
malaria, falciparum;
Artemisinins;
- From:Journal of Malaria and parasite diseases Control
2004;0(3):40-46
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
65 patients with uncomplicated Pl.falciparum malaria were monitored during 28 days after 5 -day -course use of artemisinine (year 1998) and 69 patients after 7 day course (year 2001). The mean fever cut time lengthened for 1,5 days in 1998 and 1,8 days in 2001.The mean parasite cut time had lengthened for 1,8 days in1998 and 2,3 days in 2001. The rate of reappearance of parasite accounted for 36,9% within 28 days follow up with 5 -day -course procedure and 7,3 % with 7 days procedure. The rate of repeated infestion was remarkable: 10/21 patients (year1998) and 3/5 (year 2001) had got recurrence. No change of EC50 was reported between the years 1998 and 2001, but an increase by 2 and 4 folds of EC90 and EC99 was reported.EC50,90 and 99% of chloroquine, mefloquine and quinine in the year 2001 decreased by 2 folds vs 1998
