Histological and mechanical properties of a new-type biopsy material
10.3969/j.issn.2095-4344.2013.34.008
- VernacularTitle:一种新型活组织材料的组织学及力学特性**☆
- Author:
Xiaosong CHEN
;
Jian ZHANG
;
Jianxin LI
- Publication Type:Journal Article
- Keywords:
biomaterials;
material biocompatibility;
tissue-engineered vessels;
autologous transplantation;
biotube;
autologous living tissue material;
tensile strength;
elongation at break;
bursting strength;
sweability;
National 863 Program of China
- From:
Chinese Journal of Tissue Engineering Research
2013;(34):6110-6115
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The biopsy material induced by foreign body is autologous tissue, which, in theory, avoids the role of immune rejection and destruction faced by non-autologous implants. This biology advantage has no way to comparison by synthetic and de-cel ular materials.
OBJECTIVE:To explore a biotube consisting of autologous cel s and extracel ular matrix and to evaluate its structure and mechanical features.
METHODS:The biotubes were prepared by embedding silicon rods as a mold intraperitoneal y. Specimens were analyzed by mechanical tests, histological observation and superficial study.
RESULTS AND CONCLUSION:It was easy to excite the biotubes prepared by embedding silicon tube
intraperitoneal y. The biotube mainly included col agen-rich extracel ular matrices and myofibroblasts appearing as elongated cel s with circumferential or longitudinal orientations. At 1 month of embedding, the wal was 70-250μm in thickness and had burst strength of (1 100±187) mm Hg (1 mm Hg=0.133 kPa), with perfect sewability. The biotubes, which possess the ability for wide adjustments in their shapes, are composed of autologous cel s and extracel ular matrices, and are an ideal graft for tissue engineering because they avoid immunological rejection and have sufficient mechanical strength.
