Oxidized sodium alginate used in an extracorporeal circulation pipe
10.3969/j.issn.2095-4344.2013.34.015
- VernacularTitle:氧化海藻酸钠应用于体外循环管路**
- Author:
Jinyou LI
;
Tong LI
;
Meili YU
;
Wenqing GAO
;
Xiaomin HU
;
Haibin LU
;
Guangdong YU
- Publication Type:Journal Article
- Keywords:
biomaterials;
biomaterials and drug controlled release;
extracorporeal circulation;
sodium alginate;
polyvinyl chloride;
coating;
anticoagulant properties;
stability;
degree of oxidation;
blood compatibility;
provincial grants-supported paper
- From:
Chinese Journal of Tissue Engineering Research
2013;(34):6159-6165
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:At present, a heparin-coated extracorporeal circulation pipe is used widely, but the price is expensive and limits its wide application.
OBJECTIVE:To screen the optimal coating condition of oxidated sodium alginate as a coating material to coat the medical polyvinyl chloride pipe and to evaluate the anticoagulant properties and the stability of the coated pipe.
METHODS:Oxidized sodium alginate was prepared with sodium periodate, and the mole ratio of sodium periodate and sodium alginate was 1:8, 1:10 and 1:12, respectively. Oxidized sodium alginate with different
degree of oxidation was coated on the surface of medical polyvinyl chloride pipes by chemical methods, then to select the best degree of oxidation. The optimal coating condition was screened through an orthogonal
experiment based on concentrations of sulfuric acid, polyethyleneimine and oxidized sodium alginate, and pH
value and temperature of oxidized sodium alginate. Additional y, the anticoagulant properties and expulsion rates of the prepared pipes were evaluated in comparison with the blank control group and heparin-coated group.
RESULTS AND CONCLUSION:The optimal oxidation degree for oxidized sodium alginate was 1:10 for the mole ratio of sodium periodate and sodium alginate. The best coating conditions were 50%concentrated sulfuric acid, 0.05%polyethyleneimine, 40 ℃ of reaction temperature, 2 g/L oxidized sodium alginate, and pH value=3.5. The oxidized sodium alginate coating group had a similar trend compared with heparin-coated group in the expulsion rate. The anticoagulant properties of oxidized sodium alginate coating group were little weaker than those of
heparin-coated group (P<0.05), but significantly better than those of the blank control group. The oxidized sodium alginate-coated extracorporeal circulation pipe has a good anticoagulant property and stability.
