Silent information regulator factor-1 regulates exercise-induced mitochondrial biogenesis in the skeletal muscle
10.3969/j.issn.2095-4344.2013.33.022
- VernacularTitle:运动诱导骨骼肌线粒体生成中沉默信息调节因子1的作用**☆
- Author:
Guohua ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2013;(33):6041-6048
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:Silent information regulator factor-1 is an energy metabolism regulator newly received attention in sports science, which playing roles in skeletal exercise-induced muscle mitochondrial biogenesis with other regulatory factors.
OBJECTIVE: To review the effect and mechanism of silent information regulator factor-1 on skeletal muscle mitochondrial biogenesis in exercise.
METHODS:The PubMed database and Highwire database were retrieved with computer for the articles on
exercise, silent information regulator factor-1 and skeletal muscle mitochondrial biogenesis from January 2000 to January 2013 with the key words of“SIRT1, AMPK, PGC-1α, mitochondrial biogenesis, skeletal muscle, exercise”in English. After primary search, the articles about the association between silent information regulator factor-1 and skeletal muscle mitochondrial biogenesis in exercise were selected. Articles on repeated experiment were excluded.
RESULTS AND CONCLUSION:Total y 165 relevant articles were selected, and articles on repetitive research were excluded, so finaly 62 articles were included. As a NAD+-depended deacetylase, silent information regulator factor-1 induced skeletal muscle mitochondrial biogenesis by up-regulated peroxisome proliferator-activated
receptor coactivator after activated during exercise. The molecular mechanism involved adenosine
monophosphate-activated protein kinase and hypoxia-inducible factor 2α. In recent years, the effect of silent information regulator factor-1 on skeletal muscle mitochondrial biogenesis was doubt, the researchers though that silent information regulator factor-1 was not required for exercise-induced muscle mitochondrial biogenesis.
Silent information regulator factor-1 plays an important role in exercise-induced muscle mitochondrial biogenesis. But protein and activity detection methods are different in experimental results.
