Analgesia after arthroscopic surgery:Randomly controlled Meta-analysis on intra-articular injection of bupivacaine placebo
10.3969/j.issn.2095-4344.2013.35.014
- VernacularTitle:关节镜治疗后镇痛：布比卡因关节腔内注射随机安慰剂对照的Meta分析
- Author:
Tuo YANG
;
Shuguang GAO
;
Wei LUO
;
Yusheng LI
;
Yilin XIONG
;
Jinpeng SUN
;
Guanghua LEI
- Publication Type:Journal Article
- Keywords:
bone and joint implants;
evidence-based medicine of bone and joint;
analgesic drugs;
bupivacaine;
intra-articular;
arthroscopic surgery;
postoperative analgesia;
placebo;
randomized control ed trial;
adverse reactions;
Meta-analysis
- From:
Chinese Journal of Tissue Engineering Research
2013;(35):6306-6313
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Pain after arthroscopic treatment can not only affect the patient’s life quality, and is not
conducive to the early reasonable exercise and functional recovery of the patients after treatment. Up to 2012, there are 18 randomized placebo-control ed trials on intra-articular injection of bupivacaine for analgesia after arthroscopic surgery, but the results are different.
OBJECTIVE:To examine the efficacy and safety of intra-articular injection of bupivacaine in the management of pain after arthroscopic surgery through randomized placebo-control ed trials.
METHODS:The MEDLINE database, Cochrane Central Register and Google Scholar database were retrieved for the randomized control ed trials on intra-articular injection of bupivacaine in the management of pain after
arthroscopic surgery up to April 2012. The key words were“bupivacaine, intra-articular, arthroscopic, postoperative pain, placebo”.
RESULTS AND CONCLUSION:Eighteen studies (n=934) were included (461 cases in bupivacaine group and 473
cases in the placebo control group). The Meta-analysis results showed the visual analog scale score of the bupivacaine group was lower than that of the placebo control group (weighted mean difference:-1.39, 95%confidence interval:-2.17 to-0.61, P<0.000 01), and the number of patients required supplementary analgesia was less than the placebo control group (relative risk:0.84, 95%confidence interval:0.62 to 1.66, P=0.010). The time from first supplementary analgesia to postoperative intra-articular injection in the bupivacaine group was longer that in the placebo control group (weighted
mean difference:157.72, 95%confidence interval:16.43 to 299.01, P<0.000 01). There was no significant difference in the incidence of side effect between two groups (relative risk:0.64, 95%confidence interval:0.29 to 1.44, P=0.48). On the basis of the currently available literature, the intra-articular of bupivacaine after arthroscopic surgery can significantly relieve pain without increasing the adverse reactions when compared with the placebo control group.
