Study on genetic epidemic of ankylosing spondylitis

VernacularTitle:强直性脊柱炎的遗传流行病学研究
Author: Junjie LI ; Jiafen JI ; Changyun LIU
Publication Type:Journal Article
Keywords: Ankylosing spondylitis; Epidemiology; Polygenic disease; Heritability
From: International Journal of Pediatrics 2013;40(4):413-415
CountryChina
Language:Chinese
Abstract: Objective To investigate the epidemiological situation and the mode of inheritance of ankylosing spondylitis (AS).Methods The AS prevalence investigation was carried out from three different areas in Shandong Province to investigate the incidence of the 80 patients' family members of sick group and calculate the heritability of AS.Results After the investigation and calculation we found the incidence of primary relatives was 7.23％,the heritability was 85.94％,the incidence of secondary relatives was 0.94％ and the heritability was 57.4％,the incidence of thirdly relatives was 0.39％,the heritability is 36.2％,the average heritability among primary,secondary and thirdly was 68.47％ ± 1.64％.Separation ratio was 0.088 9.Conclusion AS is a polygenic disease,its average heritability was 68.47％ ± 1.64％ and separation ratio is 0.088 9.By this research,the incidence risk of AS patients' pedigree offspring can be assessed,then strengthen protective factors to reduce the incidence of the disease to provide the basis for eugenics.