The gene of EVI 1 in leukemia
10.3760/cma.j.issn.1673-4408.2013.04.020
- VernacularTitle:EVI1基因在白血病中的研究进展
- Author:
Min JIANG
- Publication Type:Journal Article
- Keywords:
Ecotropic viral integration site;
Leukemia
- From:
International Journal of Pediatrics
2013;40(4):398-401
- CountryChina
- Language:Chinese
-
Abstract:
EVI1 gene mainly controls embryo development.3q rearrangement,MLL translocations,monosomy 7,which react with other genes,can lead to EVI1 aberrant expresion or fusion gene.Recent studies have shown aberrant expression of EVI1 gene in parts of acute lymphatic leukemia,acute myeloid leukemia and chronic granulocytic Leukemia and correlation with poor prognosis.Leukemogemc mechanism include epigenetic modifications,transcriptional control,regulation of signaling pathways,upregulation of cell adhesion,proliferation,and colony formation and antiapoptosis.Drugs of genetic therapy include epigenetic agents,mTOR inhibitor,human ITGA6/ITGB4 complex antibody and CD52 monoclonal antibody.
