The multi-drug resistance mechanism and treatment of multidrug-resistant acinetobacter baumannii
10.3760/cma.j.issn.1673-4408.2013.04.015
- VernacularTitle:多重耐药鲍曼不动杆菌的耐药机制及治疗进展
- Author:
Chongbing YAN
- Publication Type:Journal Article
- Keywords:
Multidrug-resistant acinetobacter baumannii;
Sulbactam;
Carbapenemase;
Polymyxin B;
Tigecycline
- From:
International Journal of Pediatrics
2013;40(4):381-384
- CountryChina
- Language:Chinese
-
Abstract:
While broad-spectrum antibiotics are widely used in these years,multidrug-resistant,extensively drug resistant,even pan drug resistant bacteria arise constantly.Acinetobacter baumannii is a common conditioned pathogen,and multidrug-resistant acinetobacter baumannii (MDRAB) has become one of the trickiest problems in nosocomial infection.The resistant mechanism of MDRAB include:producing antimicrobial inactivator,changing target site or cell function,adventitia barrier and effiux pump.Currently,sulbactam,carbapenem,polymyxin,tetracycline and some other antibiotics are used in MDRAB infection.Since lacking of extensive clinic study,there is no guideline up to now,the experience is especially less in pediatrics.
