DNA methylation and congenital heart disease pathogenesis
10.3760/cma.j.issn.1673-4408.2013.04.012
- VernacularTitle:DNA甲基化与先天性心脏病发病机制的研究进展
- Author:
Ting LIU
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
DNA methylation;
Epigenetics;
Gene;
Direct sequencing
- From:
International Journal of Pediatrics
2013;40(4):370-374
- CountryChina
- Language:Chinese
-
Abstract:
The roles that DNA methylation play in the congenital heart disease have recently begun to come to light.The abonormal DNA meghylation pattern on key regulation gne during heart development,such as T-box,CHD7,LINE1,methylenetrahydrofolate reductase,changed the expression of those gene,and increased the incidence of the congenital heart disease.The DNA methylation could be determined by sequencing,methylationsensitive PCR and combined bisulfate restriction anylysis.To study the DNA methylation will not only reveal the mechanism of congenital heart disease,but also provide a new strategy for clinical diagnosis and treatment.
