Expression and significance of Wnt11 in kidney
10.3760/cma.j.issn.1673-4408.2013.04.007
- VernacularTitle:Wnt11基因在肾脏的表达及意义
- Author:
Xiaojuan NAN
- Publication Type:Journal Article
- Keywords:
Wnt11 signaling pathways;
Renal development;
Renal fibrosis
- From:
International Journal of Pediatrics
2013;40(4):352-354
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling pathways is a hot focus in recent years,which plays important regulatory roles in cell proliferation,differentiation and migration.Wnt signaling pathways include classical Wnt signaling pathways and non classical Wnt signaling pathways.Wnt11 is a very important signal molecule in the nonclassical WNT signaling pathways and kidney development,which plays a positive regulatory effect in the development of kidney and become silent in mature kidney.Studies have shown that Wnt11 re-express in the renal fibrosis.This paper discusses the function of the Wnt11 in kidney development and the relationship between Wnt11 and renal fibrosis.