Advances in intestinal mucosal barrier in the pathogenesis and treatment of inflammatory bowel disease
10.3760/cma.j.issn.1673-4408.2013.04.008
- VernacularTitle:肠黏膜屏障在炎症性肠病的发病机制和治疗中的研究进展
- Author:
Nan LIN
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Intestinal mucosal barrier;
Pathogenesis;
Treatment
- From:
International Journal of Pediatrics
2013;40(4):355-358
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD) is a recurrent chronic nonspecific intestinal inflammatory disease which can be seen at any age.Its pathogenesis is not clear and the incidence is increasing.Intestinal mucosal barrier has the function to isolate intestinal contents and internal environment which can prevent pathogens invade to lamina propria mucosae and maintain organic homeostasis and normal activities.Impairment of intestinal barrier is a key event in various gastrointestinal diseases,such as IBD.The dysfunction of intestinal mucosal mechanic barrier,immunologic barrier and biologic barrier or their interactions all can induce gastrointestinal diseases.Identifying the specific mechanism of intestinal mucosal barrier impairment in pathogenesis of IBD,maintaining and restoring intestinal barrier function is becoming a new strategy in the treatment of IBD.
