Long-term anti-epileptic drug therapy and metabolic bone disase in children
10.3760/cma.j.issn.1673-4408.2013.04.005
- VernacularTitle:抗癫(癇)药物长期应用与儿童代谢性骨病
- Author:
Qian WANG
- Publication Type:Journal Article
- Keywords:
Antiepileptic drug;
Metabolic bone disease in children
- From:
International Journal of Pediatrics
2013;40(4):345-348
- CountryChina
- Language:Chinese
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Abstract:
Epilepsy is a common chronic brain dysfunction in children.Studies have showed that antiepileptic drugs (AED) affect the hydroxylation of vitamin D in liver and kidney and inhibit the calcification of bone,mainly by up-regulating cytochrome oxidase P450 and promoting the resolution of vitamin D,and then increasing serum parathyroid hormone compensatory.Long-term use can cause children metabolic bone disease occurrence,clinical manifestations include bone pain,short stature,rickets,teeth agenesis,fracture,etc.AED firstly affect the hormones related to bone metabolism in vivo,so that the present researches focus on biochemical tests and measurement of sclerotin and bone density.In the children's long-term use of antiepileptic drug treatment at the same time,the application of Vitamin D,calcium and exercise can prevent the occurrence of metabolic bone disease.
