Advances of CD40 ligand-CD40 and kidney diseases
10.3760/cma.j.issn.1673-4408.2013.04.001
- VernacularTitle:CD40-CD40L与肾脏疾病研究进展
- Author:
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
CD40;
CD40 ligand;
Glomerulonephritis;
Lupus nephritis
- From:
International Journal of Pediatrics
2013;40(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
It has been well established that interactions between CD40 and CD40L,expressed in a variety of cell types including platelets,vascular endothelial cells,and immune cells,are actively involved in the development of glomerulonephritis,lupus nephritis,and the other kidney disease caused by immunological and unimmunological factors,and that tubular cells expression of CD40 was correlated well with the degree of tubulointerstitial inflammation and injury.The development of therapeutic strategies specifically accommodating CD40/CD40L seem promising against renal glomerular disease.The paper reviews the new advances in this
