T helper cell 17 (Th17) and its role in solid organ transplantation
10.3760/cma.j.issn.1007-8118.2013.08.024
- VernacularTitle:辅助性T细胞17及其在器官移植中的作用
- Author:
Yong SHI
;
Yurong LIANG
- Publication Type:Journal Article
- Keywords:
T helper cell 17;
Rejection;
Immune tolerance
- From:
Chinese Journal of Hepatobiliary Surgery
2013;19(8):636-640
- CountryChina
- Language:Chinese
-
Abstract:
T helper 17 cells (Th17) are a novel subset of CD4+ T cells that undergo differentiation from naive CD4 T cells through the activation of a key nuclear transcription factor,retinoic-acid-receptor-related orphan receptor γt (RORγt),and in the presence of multiple cytokines,such as transforming growth factorβ1 (TGF-β1),interleukin6 (IL-6),as well as IL-23.Th17 cells induce their biological effect by secreting IL-17A and other cytokines.Research has demonstrated that Th17 cells have an intimate relationship with acute/chronic transplant reactions and that Th17 cell lineages have the possibility to become the new target for treating transplant rejections.Identification of Th17 cells also provides an additional strategy for inducing immune tolerance.
