Function of calcitonin gene-related peptides in chronic morphine tolerance and hyperalgesia
10.3969/j.issn.1000-8179.20130964
- VernacularTitle:降钙素基因相关肽在慢性吗啡耐受及相关痛觉过敏中的作用*
- Author:
Yuxin ZHENG
;
Yonghao YU
- Publication Type:Journal Article
- Keywords:
drug tolerance;
morphine;
hyperalgesia;
calcitonin gene-related peptide (CGRP)
- From:
Chinese Journal of Clinical Oncology
2013;(16):997-1000
- CountryChina
- Language:Chinese
-
Abstract:
Pain is a common symptom in patients with terminal cancer and is the main factor that affects their quality of life. Morphine is commonly used for the treatment of acute and chronic pain, but the long-time application of morphine results in morphine tolerance and hyperalgesia, which restrict the clinical applications of the anesthetic. In this review, pertinent studies on morphine over recent years were summarized and analyzed, and the mechanism of morphine tolerance and hyperalgesia were discussed, specifically on the function of calcitonin gene-related peptide (CGRP) in clinical practice. The authors analyzed the relationship between the plastic changes in the nervous system and chronic morphine application in terms of CGRP up-regulation based on its molecular biology charac-teristics and distribution, the relationship between CGRP and chronic application of morphine, and between CGRP and hyperalgesia. The effect of CGRP up-regulation on the nociceptive system and the relationship between CGRP up-regulation and the formation of hy-peralgesia were also analyzed. We discussed the sensitized effect of CGRP up-regulation on the nociceptive system, which promotes morphine tolerance and hyperalgesia. This study provides a framework for treating morphine tolerance and can be used as a guide for further research on the topic.
