The feasibility of GFP positive Lewis lung cancer cell line 3LL intracarotid injected to establish brain metastasis animal model *
10.3969/j.issn.1671-8348.2013.23.021
- VernacularTitle:GFP标记Lewis肺癌细胞3LL颈内动脉注射建立脑转移癌动物模型的可行性研究
- Author:
Lei XU
;
Wei ZHOU
;
Ke LIU
- Publication Type:Journal Article
- Keywords:
lung cancer;
brian metastases;
intracarotid injection;
animal model
- From:
Chongqing Medicine
2013;(23):2754-2757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the feasibility and surgical techniques of C57BL/6 mice intracarotid injected Lewis lung cancer cell line 3LL to establish a kind lung cancer brain metastasis animal model .Methods Green fluorescent protein(GFP) positive 3LL cells were intracarotid injected into C57BL/6 mice to establish lung cancer brain metastases animal models ,then tumor growth and survival time were analyzed .Results The intracarotid injection animal model could establish brain metastases animal model success-fully .Conclusion The intracarotid injection is an effective method to establish cancer brain metastatic animal model .
