The effects of Saccharomyces boulardii powder on preventing antibiotic-associated diarrhea in children with pneumonia
10.3760/cma.j.issn.1673-4408.2013.04.027
- VernacularTitle:布拉氏酵母菌散剂预防肺炎儿童抗生素相关性腹泻的疗效观察
- Author:
Hong YE
;
Qiankun LAI
;
Guanghua LIU
;
Lumin CHEN
;
Zijing WANG
- Publication Type:Journal Article
- Keywords:
Antibiotic-associated diarrhea;
Probiotics;
Prevention;
Children
- From:
International Journal of Pediatrics
2013;40(4):423-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this randomized,double-blind,placebo-controlled trial was to evaluate the efficacy of the Saccharomyces boulardii (S.boulardii) power in preventing antibiotic-associated diarrhea (AAD) in hospitalized children with pneumonia.Methods Two hundred and forty-five hospitalized children with pneumonia were randomly divided into two groups,group 1 treated with antibiotics and S.boulardii power (n =104),and group 2 with antibiotics and placebo,along with S.boulardii power and zinc when suffered from diarrhea (n =141).All children received montmorillonite powder and fluid replacement therapy for diarrhea.The stool frequency and consistency were observed.Diarrhea incidence,diarrhea and pneumonia duration of treatment,and therapeutic effect were recorded.Results AAD is more prevalent in group 2 than in group 1 (P ＜0.05).A 55.7％ relative risk reduction in AAD was seen in group 1 compared with group 2 (RR =0.443,95％CI 0.233 ～ 0.845,P =0.012).Patients with preventive treatment of S.boulardii power in broup 1 had lower AAD incidence compared with those in group 2 (P ＜ 0.05).Both the diarrhea and pneumonia duration of treatment in group 1 were shorter than that in group 2(P =0.001 for diarrhea duration,P =0.030 for pneumonia duration,respectively).No drug related adverse reactions were found during the observation period.Conclusion Preventive use of S.boulardii power may effectively reduce the risk of AAD,improve therapeutic effect,and shorten hospital stays for hospitalized children with pneumonia.
