Clinical application of serological detection in primary hepatic car-cinoma and metastatic hepatic carcinoma patients
10.3969/j.issn.1000-8179.20131078
- VernacularTitle:原发性与转移性肝癌患者血清学检测的临床应用*
- Author:
Ze LI
;
Yunli ZHOU
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
primary hepatic carcinoma;
metastatic hepatic carcinoma;
serology;
tumor marker
- From:
Chinese Journal of Clinical Oncology
2013;(16):971-974
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of serological test indicators in the identification of primary and metastatic liver cancers. Methods:We detected the serum levels of ALT, AST, ALP, TBIL, DBIL, GGT, CHE, 5'-NT, CA199, CEA, and AFP in primary hepatic carcinoma (PHC;120 cases), metastatic hepatic carcinoma (MHC;135 cases), and no liver metastatic control (135 cas-es) groups. The methods used were variance analysis and Scheffe test. ROC curve analysis was used to determine the diagnostic value of CA199 , CEA, and AFP in PHC and MHC. Results:The difference between the serum levels of AST, ALP, GGT, 5'-NT, AFP, and CEA of the PHC and MHC groups was statistically significant (P<0.05). The AFP, CEA, and CA199 areas under the ROC curve of the PHC and MHC groups revealed that AFP diagnosis of primary liver cancer had certain accuracy, whereas CEA and CA199 have some diagnostic value in differentiating primary and metastatic liver cancers. Conclusion: The detection of serum levels of AST, GGT, 5'-NT, AFP, CA199, and CEA in malignant tumor was a preliminary diagnosis of liver metastasis and can provide evidence for the dif-ferential diagnosis of PHC and MHC.
