Expressions and prognostic value of metadherin, E-cadherin, and β-catenin in patients with hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2013.08.011
- VernacularTitle:异黏蛋白、上皮钙黏蛋白、β链蛋白在肝细胞癌中的表达及预后研究
- Author:
Xujian CHEN
;
Yiyu SHEN
;
Jing WANG
;
Zhengxiang ZHONG
;
Hongjia PAN
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Metadherin;
E-cadherin;
β-catenin;
Prognosis;
Risk factor
- From:
Chinese Journal of Hepatobiliary Surgery
2013;19(8):597-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of metadherin (MTDH),E-cadherin and β-catenin in the tissues of hepatocellular carcinoma (HCC),to investigate the relationship between them and the clinical-pathological features,and to evaluate the prognostic values after surgical resection for hepatocellular carcinoma.Methods The protein expressions of MTDH,E-cadherin and β-catenin were studied by immunohistochemistry in tumor tissues of 107 HCC patients who underwent curative surgical resection.The data were correlated with the clinical-pathological data,tumor free time and recurrence rate.Results Positive expression of MTDH and nuclear β-catenin accumulation were correlated with the Edmondson grade (P＜0.05) and decreased E-cadherin expression was correlated with the preoperative serum level of α-fetoprotein (AFP) (P＜0.05).All these expressions were associated with a shorter tumor-free survival and a higher recurrence rate (P＜0.05).Positive MTDH expression was correlated with decreased E-cadherin expression and nuclear β-catenin accumulation (P＜0.05).On Cox regression analysis,MTDH was an independent risk factor of tumour recurrence (RR=3.431,CI=1.254～ 7.318).Conclusions Positive MTDH expression,decreased E-cadherin expression,and nuclear β-catenin accumulation indicated a higher recurrence rate after curative surgical resection for HCC.MTDH was an independent risk factor of recurrence.
