Study on Antioxidative Dosage-effect Relationship of Marigold Lutein
10.3969/j.issn.1005-5304.2013.09.009
- VernacularTitle:万寿菊叶黄素抗氧化作用量效关系研究
- Author:
Jinsheng LI
;
Ran JIN
;
Xia CHEN
;
Feng YUE
;
Dan LIU
;
Hantao ZHANG
;
Zuguang YE
- Publication Type:Journal Article
- Keywords:
Marigold;
lutein;
mouse;
D-galactose;
antioxidation;
dosage-effect Relationship
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(9):26-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the antioxidative dosage-effect relationship of Marigold lutein, and provide experimental data for clinical use. Methods The mice were randomly divided into seven groups:blank control group, model control group, 1 mg/kg lutein group, 5 mg/kg lutein group, 25 mg/kg lutein group, 125 mg/kg lutein group and 625 mg/kg lutein group. The mice in blank control group were dealt with saline solution by intraperitoneal injection, the others were dealt with D-galactose (120 mg/kg) by intraperitoneal injection for seven weeks to make oxidative damage model, meanwhile the mice were given corresponding dose of the drug. Subsequently, the level of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in the serum were measured, and the antioxidative dosage-effect relationship was observed. Results The 1, 5, 25 mg/kg lutein reduced the MDA level and increased SOD activity, and the 125, 625 mg/kg dose of lutein did not show significant antioxidant activity. Conclusion Lutein has significant antioxidant activity in mouse dealt with D-galactose within the dose range of 1-25 mg/kg. The results suggest that the clinical dosage range of lutein should be kept within reasonable limits.
