Necrobiotic xanthogranuloma with immunoglobulin G kappa paraproteinemia and eve involvement

VernacularTitle:伴IgG-κ型副球蛋白血症和眼睛受累的渐进坏死性黄色肉芽肿
Author: Xiangang FANG ; Huixian LI ; Xiujuan SHAN ; Shujie TAO ; Zhenhua WANG
Publication Type:Journal Article
From: Chinese Journal of Dermatology 2013;46(9):679-680
CountryChina
Language:Chinese
Abstract: A 74-year-old man presented with yellowish red nodules and plaques on the trunk for more than one year.Physical examination showed more than 20 scattered,irregularly shaped,well-demarcated,yellowish red nodules and plaques measuring 0.5-15 cm in diameter on the trunk.The plaques on the right lower abdomen showed central ulceration and atrophy with scar formation.Plasma protein electrophoresis revealed that the levels of immunoglobulin G (IgG) and kappa light chain were 18.3 g/L and 20.70 g/L respectively.Histopathologically,large necrobiotic areas and granuloma were observed alternately in the dermis and subcutis.There were numerous Touton giant cells,foreign body giant cells and foamy histiocytes in the granuloma,and many cholesterol clefts were found in the center of necrobiotic areas with the formation of lymphoid follicles in some regions.Both eyes of the patient were involved to different degrees.He was diagnosed as necrobiotic xanthogranuloma with IgG kappa paraproteinemia and eve involvement.