Applications of mesenchymal stem cells in the study of hepatic regeneration

VernacularTitle:间充质干细胞在肝再生研究中的应用
Author: Aixing DING ; Yabin YU ; Qingfeng HUANG ; Ning WU ; Jianmin BIAN
Publication Type:Journal Article
Keywords: Mesenchymal stem cells; Liver regeneration
From: Chinese Journal of Hepatobiliary Surgery 2013;19(7):556-558
CountryChina
Language:Chinese
Abstract: Remarkable progress has been achieved in the transplantation of mesenchymal stem cells (MSCs)for the treatment of liver injury and hepatic failure.However,there are obstacles such as low engraftment capacity,tumorigenesis,and a fibrogenic potential that all hamper the use of MSCs in clinical trials.Therefore,it is worthwhile to talk about the alternatives that will increase the safety and efficacy of MSCs therapy.To date,applications of MSCs-derived hepatocytes,genetically modified MSCs,or MSC-conditioned medium for promoting liver regeneration have shown encouraging results.This review summarizes the current applications of MSCs in the study of hepatic regeneration.