Chuju total flavonoids control the SFRP4 expression in Wnt pathway in rheumatoid arthritis model rats

VernacularTitle:滁菊总黄酮调控类风湿性关节炎模型大鼠滑膜组织Wnt通路SFRP4表达
Author: Chenggui MIAO ; Jian LIU ; Yonghe ZHANG ; Min GAO ; Qingyu CHEN ; Huaqi HE
Publication Type:Journal Article
Keywords: Chuju total lfavonoids; rheumatoid arthritis; sonyvium; SFRP4; Wnt; β-catenin
From: Journal of Central South University(Medical Sciences) 2013;38(7):715-721
CountryChina
Language:Chinese
Abstract: Objective:To determine the effect of Chuju total flavonoids (CJTF) on the secreted frizzled-related protein 4 (SFRP4) expression in Wnt pathway in rheumatoid arthritis (AR) model rats. Methods:hTe role of CJTF in the treatment of AR model rats was evaluated by rat arthritis score and paw edema score. The expression regulation of the SFRP4,β-catenin and C-myc in Wnt pathway in AR model rats was detected by RT-PCR and Western blot atfer CJTF gavage treatment. Results:Atfer CJTF treatment, the rat arthritis score and paw edema score in AR model rats were signiifcantly decreased when the AR model rats were treated with CJTF, the SFRP4 expression was signiifcantly up-regulated, while theβ-catenin and C-myc gene expression were signiifcantly down-regulated in AR model rat synovial tissues. Conclusion:CJTF has significant therapeutic effect and inhibitory effect on Wnt pathway activation by targeting SFRP4 in AR model rat synovium.