Immunotoxicity study of Ginenoside Compound K Injection

VernacularTitle:人参皂苷Compound K注射液免疫毒性评价
Author: Chao SONG ; Luping DONG ; Shuzhen LI
Publication Type:Journal Article
Keywords: Ginenoside compound K injection; Active systemic anaphylaxis; Passive cutaneous anaphylaxis
From: International Journal of Traditional Chinese Medicine 2013;35(9):789-791
CountryChina
Language:Chinese
Abstract: Objective Evaluate the immunotoxicity of Ginenoside Compound K Injection.Methods Active Systemic Anaphylaxis (ASA)tests and Passive Cutaneous Anaphylaxis (PCA)tests were used to evaluate Ginenoside Compound K Injection.Results In the ASA tests,positive control group showed pole-strength anapbylaxis,both the high-dose group and the low-dose group of Ginenoside Compound K Injection didn't produce allergic reaction and the body weights of all groups showed no significant differences.In the PCA tests,all rats of positive control group caused blue spots with their diameters bigger than 5 mm (diameters on the left side of blue spots was (10.1± 3.34) mm and diameters on the right side of blue spots was(7.57± 1.94)mm.Serum IgE was significantly increased.While both high dose and low dose of Ginenoside Compound K Injection group didn't show blue spots with their diameters greater than 5 mm and their IgE levels showed no significant differences compared with negative control group.Conclusion Ginenoside Compound K Injection showed no immunotoxicity under these experimental conditions.