Biological effects of hypoxia on mesenchymal stem cell
10.3760/cma.j.issn.1673-4181.2013.03.013
- VernacularTitle:低氧对间充质干细胞生物学特性的影响
- Author:
Wenjun ZHU
;
Min LIANG
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Hypoxia;
Cell proliferation;
Cell differentiation;
Migration
- From:
International Journal of Biomedical Engineering
2013;36(3):184-188
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cell (MSC) resides in a relatively hypoxia niche (volume fraction 1％～7％)compared to normoxia (20％).MSC cultured in hypoxia condition shows different biological features from those in normoxia condition.Hypoxia inducible factor-1 α (HIF-1 α),as one of main transcription factors in hypoxia,participates in the regulation of cell proliferation,differentiation,apoptosis,glycolysis and angiogenesis.Recent researches show that HIF-lα also plays an important role in regulating the survival,differentiation and migration of MSC.It turns out that hypoxia can improve survival and migration of MSC,enhance chondrogenesis but inhibit adipogenesis through HIF-lα and its downstream genes.However,whether hypoxia promotes or impedes osteogenesis remains controversial.Such differences can be caused by variances of tissue origination,oxygen concentration and culture condition.The comparison of different researches should be based on the same experiment condition.This review focuses on the influence of hypoxia on proliferation,apoptosis,differentiation and migration of MSC.
