The relationship of breast cancer molecular subtype and location and time of recurrence metastasis
10.3760/cma.j.issn.1008-1372.2013.07.010
- VernacularTitle:乳腺癌分子分型与复发转移部位、时间的相关性研究
- Author:
Hebing WANG
;
Jian XIAO
;
Wenxin CHEN
;
Binglin YANG
;
Sumei HAN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Protein isoforms;
Recurrence;
Neoplasm metastasis;
Receptor,epidermal growth factor;
Prognosis
- From:
Journal of Chinese Physician
2013;15(7):904-907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk distribution of breast cancer for location and time of recurrence metastasis in molecular subtype.Methods We studied retrospectively the female patients who were diagnosed as invasive ductal breast cancer in our hospital from July 2004 to June 2012,detected ER,PR,and HER2 expressions in the paraffin sections.The patients with recurrence metastasis were divided into local recurrence and distant metastasis with the first transfer site as standard for analyzing the distribution in molecular subtype and the time of the first site of recurrence metastasis.Results Sixty two patients were encountered recurrence metastasis,including 23 patients with local recurrence,and 39 patients with distant metastasis,death 11.The rates of distant metastasis for patients who belonged to HER2 type and basal-like type were higher than that of local recurrence (P =0.01,P =0.001).The risk distribution of recurrence metastasis time in molecular recurrence metastasis showed that 35 percent of recurrence metastasis time of luminal A type was first 3 years,75 percent of molecular subtype of basa1-1ike type recurrence metastasis time in first 3 years and advanced.The peak of luminal B and HER2 type was first 3 years,and very low in 5 years.Conclusions Molecular subtype of breast cancer is an important complement for TNM method in accurately assessing the patients of recurrence metastasis for location and time,and is helpful for the individual screening of patients for recurrence metastasis.
