Expression and clinical significance of IL-17-producing CD4+ T and IL-17-producing CD8+ T cells in the peripheral blood of lung cancer patients
10.3760/cma.j.issn.1006-9801.2013.07.010
- VernacularTitle:肺癌患者外周血白细胞介素-17+CD4+T细胞和白细胞介素-17+CD8+T细胞表达的意义
- Author:
Jianhong HUANG
;
Yanfeng WANG
;
Jinfang ZHAI
;
Li SHI
;
Wen SU
;
Fucai HAN
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Th17 cells;
IL-17-producing CD8+ T cells;
Tumor immunity
- From:
Cancer Research and Clinic
2013;25(7):463-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of Th17 and Tc17 cells in peripheral blood of lung cancer patients.Methods The percentages of Th17 cells and Tc17 cells in 60 lung cancer patients and 40 healthy controls were evaluated by flow cytometry analysis (FCM).Results The percentages of Th17 cells [(1.795±0.623) ％] and Te17 cells [(0.865±0.357) ％] in lung cancer group were significandy higher than those in controls [(1.405±0.256) ％,(0.640 ±0.204) ％],(t =28.944,P ＜ 0.001,t =14.051,P ＜ 0.001).Furthermore,there was a positive correlation between Th17 cells and Tc17 cells in the two groups (lung cancer group r =0.770,P ＜ 0.05,control group r =0.532,P ＜ 0.05).The percentages of Th17 cells and Tc17 cells were closely associated with clinical stage (F =4.882,P =0.011,F =3.633,P =0.033),but not connected with pathological types (P ＞ 0.05,P ＞ 0.05).Conclusion The overexpression of Th17 and Tc17 may be involved in the occurrence and development of lung cancer,which can be used as new indicators for immunologic function of lung cancer patients,and provide a reference in monitoring the disease.
