Role of serum folate, polymorphisms related reduced folate carrier gene and methionine synthase reductase gene in cervical cancer
10.3760/cma.j.issn.1006-9801.2013.07.002
- VernacularTitle:叶酸及其代谢相关的还原型叶酸载体、甲硫氨酸合成酶还原酶基因多态性与子宫颈癌关系的研究
- Author:
Fang CHEN
;
Jintao WANG
;
Ling DING
;
Qin ZHOU
;
Yuanyuan WU
- Publication Type:Journal Article
- Keywords:
Folic acid;
Gene,reduced folate carrier;
Gene,methionone synthase reductase;
Polymorphism,single nucleotide;
Uterine cercical neoplasms
- From:
Cancer Research and Clinic
2013;25(7):437-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the possible association among serum folate,polymorphisms related reduced folate carrier gene (RFC-1) AS0G,methionine synthase reductase gene (MTRR) A66G,and cervical cancer,and to provide clues for the etiology of cervical cancer.Methods Based on a hospital-based case-control study,107 cases diagnosed as cervical cancer pathematologically and 107 controls with hysteromyoma,were selected by frequency,matched with age and habitation.Serum folate concentration was detected by RIA and polymorphism RFC-1 A80G and MTRR A66G was examed by RFLP-PCR.Results Serum folate concentration in patient group [(1.86±0.60) ng/rml] was significantly lower than that in control group [(2.30 ± 1.14) ng/ml],and risk of cervical cancer increased with the decreased serum folate levels (x2trend =12.57,P =0.001).Risks to catch cervical cancer for women with RFC-1 80 GG were 2.42 times (95 ％ CI 1.01-5.81) as much as for those with RFC-1 80 AA,and 1.65 times (95 ％ CI 0.77-3.53) for those with RFC-1 80 AA and RFC-1 80 AG,risks to catch cervical cancer for women with MTRR 66 GG were 1.35 times (95 ％ CI 0.40-4.56) as much as for those with MTRR 66 AA and 1.26 times (95 ％ CI 0.38-4.16) for those with RFC-1 80 AA and RFC-1 80 AG.Conclusion Serum folate deficiency to a certain degree can increase the risk of cervical cancer.RFC-1 A80G mutation may be a risk factor for cervical cancer and homozygous (GG) gene may increase the susceptibility of cervical cancer.MTRR A66G gene mutation may have nothing to do with cervical cancer.
