Analysis of endoscopic and pathological features of 66 cases with rectum neuroendocrine neoplasm
10.3760/cma.j.issn.0254-1432.2013.08.006
- VernacularTitle:66例直肠神经内分泌肿瘤肠镜下特征和病理特征分析
- Author:
Xiaohong MIN
;
Juntao WANG
;
Jingping YUAN
;
Li LI
- Publication Type:Journal Article
- Keywords:
Neuroendocrine tumors;
Rectal neoplasms;
Proctoscopy;
Neoplasm metastasis
- From:
Chinese Journal of Digestion
2013;33(8):528-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the endoscopic and pathological characteristics of rectum neuroendocrine neoplasm (NEN).Methods From January 2005 to May 2012,the endoscopic and pathological data of 66 patients with rectum NEN were collected and graded according to historistic grade of gastroenteropancreatic-neuroendocrine neoplasm (GEP-NEN) by World Health Organization (WHO).The factors related with the metastasis of neuroendocrine tumor (NET) and neuroendocrine cancer (NEC) were analyzed by Chi square test and Fisher exact probability method.Results The locations of 66 NEN cases were between three and 15 cm from the anus.The diameters of 54 cases were less than 1 cm and under endoscopy the appearance of most tumors was submucosal hemispherical polypoid bulge.The diameters of nine cases were over 1 cm but less than 2 cm,of which the appearance of five cases was submucosal thickening or sessile polypoid bulge.The diameter of three cases was over 2 cm and the appearance was cauliflower-like or polypoid tumor which caused annular lumen stenosis.Sixty-one cases were NET (grade G1),three cases were NEC (grade G3) and two cases were mixed adenoendocrine carcinoma with both NEC and adenocarcinoma components.The metastasis of NET and NEC was not related with gender (x2 =0.158,P＞0.05) and age (Fisher exact probability method,P＞ 0.05),however was related with the diameter of tumor (Fisher exact probability method,P＜0.05).Conclusions NEN is a tumor with variety endoscopic characteristics and pathological features.The metastasis of NET and NEC seems not related with gender and age,but related with diameter.
