Pre-ischemia physical activity improved cognition and modified ascorbate change in medial prefrontal cortex after cerebral ischemia
10.3760/cma.j.issn.0254-1424.2013.07.003
- VernacularTitle:预运动对脑缺血大鼠前额叶皮质抗坏血酸水平及学习记忆能力恢复的影响
- Author:
Xiangjiang RONG
;
Jun ZHOU
;
Yuqin ZHANG
;
Xiaolin ZHANG
;
Haixu LIU
;
Kun LIU
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
In vivo microdialysis;
Medial prefrontal cortext;
Ascorbate;
Passive avoidance
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2013;35(7):519-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of pre-ischemia physical activity on cognition and ascorbate content in medial prefrontal cortex (mPFC) after cerebral ischemia.Methods Twenty-four Sprague-Dowley rats were enrolled in this study and randomly divided into the following 4 groups:running-ischemia group,running group,ischemia group and shame operation group.Cerebral ischemia was brought about by permanent 2 vessels occlusion (2-VO) method.Treadmill running was used as physical activity training.Ascorbate in mPFC was monitored with in vivo microdialysis coupled with on-line electrochemical flow cell analysis.Passive avoidance was used to test cognitive function at 24 hours after 2-VO cerebral ischemia.Results Neurochemistry study showed that ascorbate level in mPFC increased within 3 hours after 2-VO ischemia and the increase was attenuated in the running-ischemia group.The baseline level of mPFC ascorbate in the four groups has no significant difference.Behavioral data indicated that 3 weeks pre-ischemia running promoted cognitive function recovery after 2-VO ischemia.Conclusion The pre-ischemia physical activity could increase the ascrobate storage in mPFC and enhance the antioxidant ability of this region.Therefore,it is one of the possible neurochemical mechanism underlying pre-ischemia physical activity for the improvement of cognitive function after cerebral ischemia.Thus pre-ischemia physical activity can be of benefit to cognition rehabilitation after stroke.
