Interaction of 5-lipoxygenase-activating protein gene polymorphisms and environmental risk factors in ischemic stroke
10.3760/cma.j.issn.1006-7876.2013.08.009
- VernacularTitle:5-脂氧合酶激活蛋白基因多态性与环境因素在缺血性卒中发生中的交互作用
- Author:
Yufei WANG
;
Congcong SHI
;
Lianlong JIAO
;
Xiaoyi GUO
;
Shuai ZHANG
;
Yiqun FU
;
Ying HE
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Stroke;
5-Lipoxygenase-activating proteins;
Polymorphism,genetic;
Gene-environment interaction
- From:
Chinese Journal of Neurology
2013;46(8):531-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the interaction between polymorphisms of rs17222919 which located in the 5-1ipoxygenase-activating protein(ALOX5AP) gene promoter and environmental risk factors in ischemic stroke(IS).Methods We conducted a case-control study involving a total of 622 cases and 631 unrelated healthy controls which were selected from Henan Han populations,and the environment risk factors were recorded.Genotyping aimed at detecting both genetic and environmental factors in relation to IS was performed by TaqMan-polymerase chain reaction technology while interaction indexes (Υ) were calculated to determine interactions and their role models.Results The rs17222919 TG (189/622,30.4％),GG (18/622,2.9％)genotype frequencies and G (225/1244,18.1％)allele frequencies in IS subjects were significantly lower than those in controls (221/631,35.0％ ; 31/631,4.9％ ; 283/1262,22.4％ ; x2 =4.117,P =0.042 ; x2 =4.457,P =0.035 ; x2 =7.294,P =0.007).Negative interactions between TG + GG genotype and hypertension,diabetes or cigarette smoking in the occurrence of IS (Υ =0.943,0.922,0.830) were observed,whose role models were all super-multiplicative models.Conclusions According to our study,ischemic stroke is the result of the interaction of genetic and environmental factors and G allele of rs17222919 may have weakened the role of environmental factors for hypertension,diabetes and cigarette smoking in IS incidence.
