Expression and significance of metallothionein in liver transplantation for patients with benign end-stage liver diseases
10.3760/cma.j.issn.0254-1785.2013.07.009
- VernacularTitle:金属硫蛋白在良性终末期肝病组织中的表达及其与肝移植受者存活的关系
- Author:
Letian WANG
;
Shan SHAN
;
Hong WANG
;
Hong CHEN
- Publication Type:Journal Article
- Keywords:
Metallothionein;
Liver transplantation;
Benign end-stage liver diseases;
Immunohistochemistry
- From:
Chinese Journal of Organ Transplantation
2013;34(7):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of metallothionein (MT) in 113 specimens of liver transplantation for patients with benign end-stage liver diseases and 10 normal liver specimens,and analyze their clinical significance and prognostic value.Method 113 specimens of liver transplantation for patients with benign end-stage liver diseases and 10 normal liver specimens were included in this study.MT in these specimens was detected by using immunohistochemistry.Cox regression model was used to analyze the multi-factors for the prognosis.Results MT levels were lower in specimens of liver transplantation for patients with benign end-stage liver diseases than in normal liver specimens.MT levels were higher in specimens of HCV-related cirrhosis than in those of autoimmune hepatic (AIH) cirrhosis,but there was no significant difference among all other groups.Conclusion MT expression level in AIH cirrhosis tissue is higher than in HCV-related cirrhosis tissue.MT is the independent influencing factor for survival following liver transplantation in patients with benign end-stage liver diseases.
