Relationship between serum total bile acid and fetal prognosis in patients with intrahepatic cholestasis of pregnancy

VernacularTitle:妊娠期肝内胆汁淤积症患者胆汁酸水平与围产儿预后关系的研究
Author: Chen HANG ; Xiaoxia ZHANG ; Yan ZHANG
Publication Type:Journal Article
Keywords: Bile acids and salts; Infant,newborn
From: Chinese Journal of General Practitioners 2013;12(8):655-657
CountryChina
Language:Chinese
Abstract: To explore the relationship between serum total bile acid concentration and fetal prognosis in patients with intrahepatic cholestasis of pregnancy (ICP).A total of 131 ICP patients were divided into mild and severe ICP groups according to serum total bile acid concentration.And another 100 normal subjects during the same period were selected as control group.Their medical records and fetal prognoses were analyzed.The serum total bile acid,liver enzyme and lipid concentration of ICP patients were all significantly higher than those of the controls (P ＜ 0.01).The fetal prognoses of ICP patients were significantly different with those of controls (P ＜ 0.05).A high serum level of total bile acid of ICP patients may produce serious adverse effects on fetal prognosis.