Influence of BK virus activation on the renal allograft function

VernacularTitle:BK病毒活化对移植肾功能的影响
Author: Xinying WANG ; Yu FAN ; Yong HAN ; Junjie XIE ; Bingyi SHI
Publication Type:Journal Article
Keywords: Kidney transplantation; BK virus
From: Chinese Journal of Organ Transplantation 2013;34(7):404-406
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of BK virus (BKV) activation in renal transplant recipients on the renal allograft function.Method Recipients receiving renal transplantation during 2010.3-2011.4 were sdected as objectives,the urine and peripheral blood samples of them were taken and real-time PCR assays were performed to detect BKV DNA at 0.5,1,3,6,9,and 12 months post-transplantation.Results Among 88 recipients,BKV viruria occurred in 27 (30.68％) patients,and sustained viruria occurred in 17 patients.37.0％ (10/27) of patients with BKV viruria developed inot BKV viremia,and sustained viremia occurred in 5 patients.The viral load in plasma was higher in patients with sustained viremia than in those with transient viremia (P＜0.05),and serum creatinine concentrations were higher when BK viremia occurred (P＜0.05).Conclusion Graft function was impaired among patients with BK viremia,and regularly monitoring BK virus in renal transplant recipients and clinical imervention based on plasma PCR results can prevent transplant kidney damage effectively.