Expression of MACC1 and C-MET proteins in hepatocellular carcinoma and its clinical relevance
10.3760/cma.j.issn.1007-631X.2013.07.014
- VernacularTitle:MACC1和C-MET蛋白在肝细胞癌组织中的表达研究
- Author:
Yupeng ZHANG
;
Zhaoyu LI
;
Hongji WEI
;
Chaofeng TANG
;
Xiaowei CHANG
;
Chao WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Proto-oncogene proteins c-met;
Metastasis-associated in colon cancer-1
- From:
Chinese Journal of General Surgery
2013;28(7):534-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical relevance of metastasis-associated colon cancer-1 (MACC1) and C-MET proteins in hepatocellular carcinoma (HCC) tissue.Methods The expressions of MACC1 and C-MET were detected in 51 specimens of HCC and paraneoplastic liver tissue,normal liver tissue in 13 healthy cases using immunohistochemistry and Western blotting.The correlations of the expressions of MACC1 and C-MET proteins were evaluated,survival rates were observed,the relationship between the expression of MACC1,C-MET proteins and the clinicopathologic features of HCC were analyzed.Results The positive rate of MACC1 and C-MET proteins was 80.4％ and 76.5％ in HCC tissue,the relative expressions were 0.645 ± 0.047 and 0.504 ± 0.023 respectively,which was significantly different from those in paraneoplastic liver tissue and normal liver tissue (respectively F =173.308,252.817,all P =0.000).The survival analysis showed that the three-year survival rate in patients with positive MACC1 and C-MET expressions was significantly lower than that in patients with negative expressions (respectively x2 =3.934,4.439,all P ＜ 0.05),the positive rate and relative expressions of MACC1 and C-MET were significantly correlated with TNM stage,portal vein cancer thrombus and pathology typing (P ＜ 0.05).Conclusions The expression of MACC1 and C-MET is associated with the malignant progression of HCC.MACC1 may serve as a independent prognostic factor for advanced HCC and a possible therapy target for the treatment of HCC.
