Effect of acute hypoxia on contractile function of isolated small pulmonary arteries in patients with moderate chronic obstructive pulmonary disease

VernacularTitle:急性低氧对中度慢性阻塞性肺疾病患者离体肺细小动脉收缩功能的影响
Author: Jianxiu CUI ; Guangyan ZHANG ; Yijing CHEN ; Jue MA ; Guodong ZHAO
Publication Type:Journal Article
Keywords: Anoxia; Pulmonary disease,chronic obstructive; Arterioles
From: Chinese Journal of Anesthesiology 2013;33(5):592-594
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of acute hypoxia on the contractile function of isolated small pulmonary arteries in patients with moderate chronic obstructive pulmonary disease (COPD).Methods Seven patients with lung cancer,of both sexes,scheduled for elective pulmonary lobectomy,with no pulmonary hypertension and with normal pulmonary function after examination,were included in the study.Six cases were diagnosed as having moderate COPD.Lung tissues 5 cm away from the tumor tissues were taken during operation and the small pulmonary arteries were isolated and divided into 2 groups:control group (n =7) and COPD group (n =6).The contractile amplitude of small pulmonary arteries was detected using vasomotor tone meter under the state of acute hypoxia.Results Contractile amplitude of small pulmonary arteries in response to hypoxic stimulus was significantly decreased in COPD group compared with control group (P ＜ 0.01).Conclusion Acute hypoxia can further reduce the contractile function of isolated small pulmonary arteries in patients with moderate COPD.