Effect of ulinastatin on brain injury in children undergoing aortic arch surgery under cardiopulmonary by-pass
10.3760/cma.j.issn.0254-1416.2013.05.016
- VernacularTitle:乌司他丁对体外循环下主动脉弓手术患儿脑损伤的影响
- Author:
Guijin HUANG
;
Shiyu SHU
;
Fuquan LUO
;
Wei LIU
;
Hongzhen XU
;
Liqun YANG
;
Mao YE
- Publication Type:Journal Article
- Keywords:
Trypsin inhibitors;
Brain injury;
Child;
Aortic arch;
Cardiopulmonary bypass
- From:
Chinese Journal of Anesthesiology
2013;33(5):579-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of unilastatin on brain injury in children undergoing aortic arch surgery under cardiopulmonary bypass (CPB).Methods Twenty ASA physical status Ⅲ or Ⅳ children of both sexes,aged 1-24 months,weighing 3-12 kg,undergoing repair of coarctation of aorta or interrupted aortic arch complicated with intracardiac malformations under CPB,were randomly divided into 2 groups (n =10 each):control group (group C) and ulinastatin group (group U).Ulinastatin 20 000 U/kg was diluted into 10 000 U/ml with normal saline and it was then injected intravenously in 3 parts (1/3 was injected via the internal jugular vein after induction of anesthesia; 1/3 at the beginning of CPB and 1/3 at 5 min before aortic unclamping).In group C the equal volume of normal saline was given instead of ulinastatin.Blood samples were taken from the radial artery after induction of anesthesia (T1),at 10 min after aortic clamping (T2),at 10 min after aortic unclamping (T3),at the end of CPB (T4),and at 6 and 24 h after termination of CPB (T5,T6) for determination of plasma S100B protein and neuron-specific enolase (NSE) concentrations.Results There was no significant difference in plasma levels of S100B protein and NSE at T1 between the two groups (P ＞ 0.05).Plasma S100B protein and NSE levels were significantly increased at T2-5 as compared to the baseline values at T1 in both groups (P ＜ 0.05).Plasma S100B protein and NSE levels were significantly lower at T2-5 in group U than in group C (P ＜ 0.05).Conclusion Ulinastatin can attenuate brain injury in children undergoing aortic arch surgery under CPB.
