Efficacy of midazolam premedication for prevention of emergence agitation after sevoflurane anesthesia in children undergoing minor surgery
10.3760/cma.j.issn.0254-1416.2013.05.005
- VernacularTitle:咪达唑仑术前用药预防短小手术患儿七氟醚麻醉恢复期躁动的效果
- Author:
Wu WANG
;
Min YAN
;
Lipei LEI
;
Lina YU
;
Fengjiang ZHANG
- Publication Type:Journal Article
- Keywords:
Dose-response relationship,drug;
Premedication;
Midazolam;
Mood disorders;
Anesthetics,inhalation;
Child
- From:
Chinese Journal of Anesthesiology
2013;33(5):541-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of midazolam premedication for prevention of emergence agitation (EA) after sevoflurane anesthesia in children undergoing minor surgery.Methods One hundred and twenty ASA physical status Ⅰ or Ⅱ paediatric patients,aged 3-9 yr,weighing 15-35 kg,scheduled for elective tonsillectomy and adenoidectomy,were randomly divided into 4 groups (n =30 each):control group (group C) and midazolam 0.25,0.50 and 0.75 mg/kg groups (groups M1-3).The 10 ml mixture of midazolam 0.25,0.50 and 0.75 mg/kg and 10％ glucose was taken orally at 30 min before anesthesia in M1-3 groups,respectively,while 10 ml of 10％ glucose was taken orally in group C.Anesthesia was induced with inhalation of sevoflurane and maintained with iv infusion of remifentanil and inhalation of sevoflurane.EA was assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale.Results Compared with group C,the PAED scores and incidence of EA were significantly decreased in groups M2 and M3 (P ＜ 0.05),and no significant change was found in group M1 (P ＞ 0.05).Compared with group M1,the PAED scores and incidence of EA were significantly decreased in groups M2 and M3 (P ＜ 0.05).There was no significant difference in the PAED scores and incidence of EA between groups M3 and M2 (P ＞ 0.05).Conclusion Premedication with oral midazolam can prevent EA following sevoflurane anesthesia in children undergoing minor surgery and the optimum dose is 0.50 mg/kg.
