Comparison of dexmedetomidine versus lidocaine for suppression of fentanyl-induced coughing during induction of general anesthesia
10.3760/cma.j.issn.0254-1416.2013.05.015
- VernacularTitle:右美托咪定与利多卡因抑制芬太尼诱发全麻诱导期患者呛咳反应效果的比较
- Author:
Dongsheng DAI
;
Liangcheng QIU
;
Xiaodan WU
;
Yanqing CHEN
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Lidocaine;
Fentanyl;
Cough reflex
- From:
Chinese Journal of Anesthesiology
2013;33(5):576-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare dexmedetomidine versus lidocaine for suppression of fentanyl-induced coughing during induction of general anesthesia in patients.Methods Two hundred ASA physical status Ⅰ or Ⅱ patients,aged 36-50 yr,undergoing elective gynecological operations under total intravenous anesthesia,were randomized into 2 groups (n =100 each):dexmedetomidine group (group D) and lidocaine group (group L).Dexmedetomidine 0.5 μg/kg was intravenously infused over 10 min at a rate of 0.05 μg· kg-1· min-1 starting from 20 min before induction of anesthesia in group D.Lidocaine 0.5 mg/kg was injected intravenously at 1 min before induction of anesthesia in group L.For induction of anesthesia,fentanyl was given first,and 2 min later the other drugs were given.The development and degree of coughing were recorded within 1 min after fentanyl injection.The occurrence of adverse events was recorded.Results The incidence of coughing was significantly higher and the degree of coughing was severer in group L than in group D (P ＜ 0.05).There was no signihicant difference in the incidences of hypotension and severe sinus bradycardia between groups D and L (P ＞ 0.05).Conclusion Dexmedetomidine 0.5 μg/kg injected before induction of anesthesia has better suppressive effect on fentanyl-induced coughing during induction of general anesthesia than lidocaine 0.5 mg/kg in patients.
