Effect of two different periodontal therapies on levels of serum inflammatory markers in elderly coronary heart disease

VernacularTitle:不同牙周治疗方法对老年冠心病患者血清炎性因子水平的影响
Author: Hong YANG ; Xingyi LI ; Na CHEN ; Yi JIANG
Publication Type:Journal Article
Keywords: Periodontitis; Coronary disease; C-reactive protein; Tumor necrosis factor-alpha
From: Chinese Journal of Geriatrics 2013;32(8):864-866
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of two different periodontal therapies on serum levels of C-reactive protein (CRP) and tumor necrosis factor-alpha(TNF-α)in elderly patients with coronary heart disease.Methods Totally 42 elderly patients with severe periodontitis were randomized into two groups:periodontal initial therapy and periodontal flap surgery group.The percentage of bleeding on probing (BOP),probing depth (PD) and serum levels of CRP and TNF-α were recorded at baseline and 12 weeks after treatment.Results The percentage of BOP,PD and serum levels of CRP and TNF-α in all patients were significantly reduced at 12 weeks after treatment as compared with baseline (all P＜0.05).Serum levels of CRP and TNF-α were lower in periodontal flap surgery than in periodontal initial therapy at 12 weeks after treatment [(3.4±9.1) μg/L vs.(2.6 ±7.9)μg/L,(4.4±1.8)mg/L vs.(3.5±2.1)mg/L,both P＜0.05].Conclusions Compared with periodontal initial therapy,periodontal flap surgery maybe better to reduce the levels of serum inflammatory markers.