The changes and the clinical significance of plasma Apelin in elderly patients with sepsis
10.3760/cma.j.issn.0254-9026.2013.08.018
- VernacularTitle:脓毒症患者血浆Apelin的变化及临床意义
- Author:
Yong WANG
;
Yi ZHENG
;
Yan FU
;
Ning DING
- Publication Type:Journal Article
- Keywords:
Sepsis;
Receptor,angiotensin,type Ⅰ;
Prognosis
- From:
Chinese Journal of Geriatrics
2013;32(8):861-863
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristic and the predicting value of plasma Apelin in elderly patients with sepsis.Methods A retrospective analysis was conducted in 26 sepsis patients aged (72.9±9.7) years in average and 30 healthy controls.Serum Apelin level was measured by ELISA.Body mass index (BMI) and C-reaction protein (CRP) were detected.Patients were divided into survival group (n=18) and death group (n 8).According to acute physiology and chronic health evaluation (APACHE) Ⅱ,patients were divided into subgroup A (n=14,APACHE Ⅱ score≤20) and subgroup B (n=12,APACHE Ⅱ score＞20).Results The Apelin concentration was higher in sepsis patients than in healthy controls [(0.38±0.15)ng/L vs.(0.19±0.12)ng/L,t=2.011,P＜0.05].The Apelin concentration was lower in survival group than in death group[(0.21 ± 0.29)ng/L vs.(0.49 ± 0.32) ng/L,t =2.094,P＜0.05].The Apelin level was increased with APACHE Ⅱ scores increment in sepsis patients (P＜0.05).Multivariable logistic analysis showed that when taking survival/death as the dependent variable and Apelin as the independent variable,the ()R value was 4.162 with 95％ CI:1.115-15.535(P＜0.05).Conclusions Increased serum Apelin level reflects the severity of illness in patients with sepsis,which is a risk factor for death in prognosis of sepsis.
