Impact of intermittent androgen deprivation therapy on prostate volume and lower urinary tract symptoms in patients with prostate cancer combined with prostatic hyperplasia
10.3760/cma.j.issn.0254-9026.2013.08.015
- VernacularTitle:间歇性抗雄激素治疗对前列腺癌和前列腺增生的患者前列腺体积及下尿路症状的影响
- Author:
Wenke HAO
;
Liuyi HUANG
;
Wenna HE
;
Wei LIU
;
Feng YU
;
Yanhua WU
;
Yunjuan QIAN
- Publication Type:Journal Article
- Keywords:
Androgen antagonists;
Prostatic neoplasms;
Prostatic hyperplasia
- From:
Chinese Journal of Geriatrics
2013;32(8):850-852
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of intermittent androgen deprivation therapy on prostate volume and lower urinary tract symptoms (LUTS) in patients with prostate cancer combined with prostatic hyperplasia (BPH),and to evaluate the clinical effect of intermittent androgen deprivation therapy as compared with conventional drug in patients with BPH.Methods Patients with prostate cancer (n=57) and BPH (n=83) were respectively treated with intermittent androgen deprivation therapy and finasteride combined with alpha-receptor antagonist.Prostate volume,international prostate symptom score (IPSS),quality of life index (QOL) and maximum urinary flow rate (Qmax) in patients were observed before and 1,3,6 and 12 months after treatment.Results The improvements in prostate volume,IPSS,QOL and Qmax were higher in prostate cancer patients treated with intermittent androgen deprivation therapy than in BPH patients treated with finasteride combined with alpha-receptor antagonist (P ＜ 0.05).Conclusions Intermittent androgen deprivation therapy can significantly reduce prostate volume and improve LUTS in patients with prostate cancer,and has a better clinical effect than finasteride combined with alpha-receptor antagonist treatment.
