Factors of cognitive function impairment and their interactions in elderly type 2 diabetes mellitus patients with mild cognitive impairment
10.3760/cma.j.issn.0254-9026.2013.08.005
- VernacularTitle:老年糖尿病轻度认知损害患者认知功能减退影响因素分析
- Publication Type:Journal Article
- Keywords:
Diabetes,type 2;
Cognition disorders;
Factor analysis,statistical
- From:
Chinese Journal of Geriatrics
2013;32(8):813-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the cognitive function impairment factors and their interactions in elderly type 2 diabetes mellitus patients with mild cognitive impairment,in order to fully evaluate the prognosis and guide the clinical treatment.Methods A total of 612 elderly type 2 diabetes patients with mild cognitive impairment were selected in this nested case-control study.Patients were divided into the cognitive decline group and the control group matched for age,sex,culture degree and paired for observation.Risk factors for cognitive function decline were determined by single factor analysis and multivariate analysis methods.The interactions between factors were analyzed by additive effects model.Results The risk factors for cognitive function decline were non married,preferring to stay at home,less reading,hypertension,smoking,alcohol,diabetic microangiopathy,long diabetes duration,hyperglycemia (OR=2.237,2.267,2.819,3.298,2.927,2.439,2.895,3.672,3.418,95％CI:1.022-4.896,1.177-4.366,1.2767.839,1.417-7.675,1.237-6.925,1.116-7.211,1.227-6.830,1.552-8.687,1.226-7.894,respectively).Diabetic microangiopathy had a interaction with smoking and drinking,their percentages of AP (AB) were 68.9％,32.9％ and relative risk ratios of RERI were 10.621,7.238 respectively.Conclusions Diabetic microangiopathy has a positive interaction with smoking,and drinking in elderly type 2 diabetes mellitus with mild cognitive impairment.
